Publications
Jan 10, 2020
Air space distension precedes spontaneous fibrotic remodeling and impaired cholesterol metabolism in the absence of Surfactant Protein C
American Journal of Respiratory Cell and Molecular Biology Jannik Ruwisch, Kirsten Sehlmeyer, Nuria Roldan, Begoña Garcia-Alvarez, Jesus Perez-Gil, Timothy E. Weaver, Matthias Ochs, Lars Knudsen & Elena Lopez-Rodriguez Abstract Surfactant protein (SP)-C deficiency is found in samples from patients with idiopathic pulmonary fibrosis, especially in familial forms of this disease. We hypothesized that SP-C may...
Nov 21, 2019
Investigating the toxicological potential of inhaled aerosols in a breathing lung-on-chip
European Respiratory Journal Yara-Maria Proust, Nuria Roldan, Nicole Schneider-Daum, Claus Michael-Lehr, Hanno Huwer, Tobias Krebs, Olivier T. Guenat, Janick D. Stucki, Nina Hobi Abstract The widespread application of nanoparticles has drawn intense concerns about their impact on the environment and human health. The major route of nanoparticles into the human body are the alveolar ducts,...
A lung-on-chip in vitro approach to study inflammation at the alveolar level
European Respiratory Journal Nuria Roldan, Aude Rapet, Giulia Raggi, Maxime Epars, Kleanthis Fytianos, Janick D. Stucki, Nicole Schneider-Daum, Claus Michael-Lehr, Hanno Huwer, Thomas Geiser, Olivier T. Guenat & Nina Hobi Abstract Pulmonary inflammatory disease is a worldwide health burden. As a common hallmark, the integrity of the alveolocapillary barrier is compromised, causing infiltration of proinflammatory...
Sep 06, 2019
Advanced in vitro lung-on-chip platforms for inhalation assays: From prospect to pipeline
European Journal of Pharmaceutics and Biopharmaceutics Arbel Artzy-Schnirman, Nina Hobi, Nicole Schneider-Daum, Olivier T. Guenat, Claus-Michael Lehr & Josué Sznitman Abstract With rapid advances in micro-fabrication processes and the availability of biologically-relevant lung cells, the development of lung-on-chip platforms is offering novel avenues for more realistic inhalation assays in pharmaceutical research, and thereby an opportunity...
