Publications
Apr 02, 2020
CD90+CD146+ identifies a pulmonary mesenchymal cell subtype with both immune modulatory and perivascular-like function in postnatal human lung
AJP Lung Cell and Molecular Physiology Limei Wang, Patrick Dorn, Soheila Zeinali, Laurène Froment, Sabina Berezowska, Gregor J. Kocher, Marco P. Alves, Melanie Brügger, Blandina I. O. Esteves, Fabian Blank, Carlos Wotzkow, Selina Steiner, Mario Amacker, Ren-Wang Peng, Thomas M. Marti, Olivier T. Guenat, Peter K. Bode, Ueli Moehrlen, Ralph A. Schmid, and Sean R....
Jan 21, 2020
Clinically relevant tissue scale responses as new readouts from organs-on-a-chip for precision medicine
Annual Review of Analytical Chemistry Olivier T. Guenat, Thomas Geiser & François Berthiaume Abstract Organs-on-chips (OOC) are widely seen as being the next generation in vitro models able to accurately recreate the biochemical-physical cues of the cellular microenvironment found in vivo. In addition, they make it possible to examine tissue-scale functional properties of multicellular systems...
Jan 15, 2020
Azithromycin has enhanced effects on lung fibroblasts from idiopathic pulmonary fibrosis (IPF) patients compared to controls
Respiratory Research Kristina Krempaska, Sandra Barnowski, Jacopo Gavini, Nina Hobi, Simone Ebener, Cedric Simillion, Andrea Stokes, Ronja Schliep, Lars Knudsen, Thomas K. Geiser & Manuela Funke-Chambour Abstract Background. Idiopathic pulmonary fibrosis (IPF) is a chronic fatal lung disease without a cure and new drug strategies are urgently needed. Differences in behavior between diseased and healthy...
Jan 10, 2020
Air Space Distension Precedes Spontaneous Fibrotic Remodeling and Impaired Cholesterol Metabolism in the Absence of Surfactant Protein C
AJR Cell and Molecular Biology Jannik Ruwisch, Kirsten Sehlmeyer, Nuria Roldan, Begoña Garcia-Alvarez, Jesus Perez-Gil, Timothy E Weaver, Matthias Ochs, Lars Knudsen, Elena Lopez-Rodriguez Abstract Surfactant protein (SP)-C deficiency is found in samples from patients with idiopathic pulmonary fibrosis, especially in familial forms of this disease. We hypothesized that SP-C may contribute to fibrotic remodeling...
