Publications
Oct 28, 2020
Organoids and lung-on-chip to study SARS-CoV-2-mediated lung injury
European Respiratory Journal Mirjam Kiener, Lea De Maddalena, Nuria Roldan, George N. Thalmann, Thomas Geiser, Nina Hobi, Marianna Kruithof-De Julio Abstract COVID-19 is an infectious disease caused by the newly discovered coronavirus named SARS-CoV-2. The virus enters the body through the airways by exploiting the angiotensin-converting enzyme 2 (ACE2) and serine proteinase TMPRSS2. Thus, especially lung epithelial cells are attacked by the virus. In the distal lung, the...
Interleukin-2 – induced vascular leak syndrome: clinically relevant in vitro recapitulation with a patient-derived lung-on-chip
European Respiratory Journal Giulia Raggi, Nuria Roldan, Virginie Micallef, Aude Rapet, Lea De Maddalena, Théo Imler, Laurène Froment, Thomas M. Marti, Ralph A. Schmid, Ekaterina Breous-Nystrom, Adrian B. Roth, Lauriane Cabon, Nina Hobi Abstract Systemic administration of Interleukin-2 (IL-2) at high doses in cancer immunotherapy has been associated with vascular leak syndrome (VLS) and pulmonary edema, a life-threatening condition. The complex mechanism of action underlying this medication’s adverse event is not yet well understood, however it has been proposed to...
Modeling alveolar barrier disruption in vitro for sepsis-induced ARDS preclinical studies
European Respiratory Journal Nuria Roldan, Giulia Raggi, Kleanthis Fytianos, Jessica Petracca, Janick Stucki, Fabian Käsermann, Nina Hobi Abstract Disruption of the alveolar barrier is one of the main features of Acute Respiratory Distress Syndrome (ARDS), a devastating disease with no pharmacological treatments available at present. Sepsis is also a common risk factor for the development of ARDS, associated with 30% of the cases. During sepsis, hemolysis takes place,...
May 05, 2020
Alveolar Dynamics and Beyond – The Importance of Surfactant Protein C and Cholesterol in Lung Homeostasis and Fibrosis
Frontiers in Physiology Kirsten Sehlmeyer, Jannik Ruwisch, Nuria Roldan, and Elena Lopez-Rodriguez Abstract Surfactant protein C (SP-C) is an important player in enhancing the interfacial adsorption of lung surfactant lipid films to the alveolar air-liquid interface. Doing so, surface tension drops down enough to stabilize alveoli and the lung, reducing the work of breathing. In...
