Publications
May 24, 2019
Nanoparticle exposure on a breathing alveolus‐on‐chip
Journal of Aerosol Medicine and Pulmonary Drug Delivery Yara‐Maria Proust, Andreas Stucki, Nicole Schneider‐Daum, Claus‐Michael Lehr, Tobias Krebs, Olivier Guenat, Janick Stucki & Nina Hobi Abstract The pulmonary alveolar barrier is one of the largest surfaces of the human body and constantly exposed to aerosols. Yet, the available in vitro systems do poorly represent the...
Jan 22, 2019
Impaired wound healing of alveolar lung epithelial cells in a breathing lung-on-a-chip
Frontiers in Bioengineering and Biotechnology. Tissue Engineering and Regenerative Medicine Marcel Felder, Bettina Trueeb, Andreas O. Stucki, Sarah Borcard, Janick D. Stucki, Bruno Schnyder, Thomas Geiser & and Olivier T. Guenat Abstract The lung alveolar region experiences remodeling during several acute and chronic lung diseases, as for instance idiopathic pulmonary fibrosis (IPF), a fatal disease,...
Dec 27, 2018
Tumor initiation capacity and therapy resistance are differential features of EMT-related subpopulations in the NSCLC cell line A549
Neoplasia Colin C. Tièche, Yanyun Gao, Elias D. Bührer, Nina Hobi, Sabina A. Berezowska, Kurt Wyler, Laurène Froment, Stefan Weis, Ren-Wang Peng, Rémy Bruggmann, Primo Schär, Michael A. Amrein, Sean R. R. Hal, Patrick Dorn, Gregor Kocher, Carsten Riether, Adrian Ochsenbein, Ralph A. Schmid & Thomas M. Marti Abstract Cell lines are essential tools to...
Nov 01, 2018
Human microvasculature-on-a chip: anti-neovasculogenic effect of nintedanib in vitro
Angiogenesis Soheila Zeinali, Colette A Bichsel, Nina Hobi, Manuela Funke, Thomas M Marti, Ralph A Schmid, Olivier T Guenat, Thomas Geiser Abstract Idiopathic pulmonary fibrosis is characterized by a progressive scarring and stiffening of the peripheral lung tissue that decreases lung function. Over the course of the disease, the lung microvasculature undergoes extensive remodeling. There...