Publications
Oct 10, 2018
Lung-on-a-Chip: The interplay of primary human epithelial and endothelial cells improves the alveolar barrier function
Toxicology Letters Andreas O. Stucki, Giulia Raggi, Serena Sigrist, Pauline Zamprogno, Nicole Schneider-Daum, Claus Michael-Lehr, Hanno Huwer, Janick D. Stucki, Nina Hobi & Olivier T. Guenat Abstract Introduction: The pulmonary alveolar barrier is one of the largest entry ports for xenobiotics into the body and consists of a thin barrier of epithelial and endothelial cells....
Acute lung injury on-chip: building a disease predictive model that emulates alveolar biomechanics
Toxicology Letters Nuria Roldan, Aude Rapet, Andreas O. Stucki, Giulia Raggi, Kleanthis Fytianos, Thomas Geiser, Nina Hobi & Olivier T. Guenat Abstract Acute lung injury (ALI) is a complex lung disease in which inflammation plays a central role. The disruption of the alveolar epithelial-endothelial barrier together with an exacerbated inflammatory response lead to influx of...
Sep 25, 2018
Medium throughput breathing human primary cell alveolus-on-chip model
Scientific Reports Janick D. Stucki, Nina Hobi, Artur Galimov, Andreas O. Stucki, Nicole Schneider-Daum, Claus-Michael Lehr, Hanno Huwer, Manfred Frick, Manuela Funke-Chambour, Thomas Geiser & Olivier T. Guenat Abstract Organs-on-chips have the potential to improve drug development efficiency and decrease the need for animal testing. For the successful integration of these devices in research and...
May 21, 2018
Incorporating mechanical strain in organs-on-a-chip: Lung and skin
Biomicrofluidics Olivier T. Guenat & François Berthiaume Abstract In the last decade, the advent of microfabrication and microfluidics and an increased interest in cellular mechanobiology have triggered the development of novel microfluidic-based platforms. They aim to incorporate the mechanical strain environment that acts upon tissues and in-vivo barriers of the human body. This article reviews...
